Endocrine Abstracts

Placental restriction (PR) of fetal growth impairs insulin action and metabolic control in postnatal life. MicroRNAs (miRNAs) are important post-transcriptional regulators, down regulating mRNA abundance or translation. We therefore determined if PR in the sheep alters miR expression in liver, skeletal muscle and adipose tissue of adult offspring and if this associates with altered abundance of their predicted molecular targets.PR was induced by pre-preg...